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An intravenous injection of urea raises the blood level immediately and the CSF level more slowly, exerting an osmotic dehydrating effect on the central nervous tissues and CSF All 24 amino acids have been isolated from the CSF The concentration of amino acids in the CSF is about one-third that in plasma Elevations of glutamine are found in hepatic coma and the Reye syndrome and of phenylalanine, histidine, valine, leucine, isoleucine, tyrosine, and homocystine in the corresponding aminoacidurias Many of the enzymes found in serum are known to rise in CSF under conditions of disease, usually in relation to a rise in the CSF protein.

None of the enzyme changes has proved to be a speci c indicator of neurologic disease with the possible exception of lactic dehydrogenase, especially isoenzymes 4 and 5, which are derived from granulocytes and are elevated in bacterial meningitis but not in aseptic or viral meningitis Lactic dehydrogenase is also elevated in cases of carcinomatous meningitis, as is carcinoembryonic antigen; the latter, however, is not elevated in bacterial, viral, or fungal meningitis As to lipids, the quantities in CSF are small and their measurement is dif cult The catabolites of the catecholamines can now be measured in the CSF Homovanillic acid (HVA), the major catabolite of dopamine, and 5-hydroxyindoleacetic acid (5-HIAA), the major catabolite of serotonin, are normally present in the spinal uid; both are ve or six times higher in the ventricular than the lumbar CSF.

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1-1, a procedural diagram by which the clinical problem is solved in a series of sequential nite steps This systematic approach, allowing the con dent localization and often precise diagnosis of disease, is one of the intellectual attractions of neurology Of course, the solution to a clinical problem need not always be schematized in this way The clinical method offers a much wider choice in the order and manner by which information is collected and interpreted In fact, in some cases, adherence to a formal scheme is not necessary at all In relation to the aforementioned syndromic diagnosis, the clinical picture of Parkinson disease, for example, is usually so characteristic that the nature of the illness is at once apparent In other cases it is not necessary to carry the clinical analysis beyond the stage of the anatomic diagnosis, which in itself may virtually indicate the cause of a disease.

The levels of both catabolites are reduced in patients with idiopathic and drug-induced parkinsonism Finally, it may be said that with continued development of microchemical techniques for the analysis of the CSF, we can look forward to a better understanding of the metabolic mechanisms of the brain, particularly in the hereditary metabolic diseases Ultra re ned methods such as gas-liquid chromatography will probably reveal many new catabolic products, the measurement of which will be of value in diagnosis and therapy Thompson has reviewed the biochemical analysis of CSF and its use for diagnostic purposes..

A function is called much the way a subroutine is called, by using the function name and passing parameters, if any parameters are required. However, a function is usually called as part of an expression, enabling the application to use the value returned by the function. Here's how a function is called:

9:

When we raise a number to the power of 2, we multiply it by itself. This is also called squaring the number. When we raise a number to the power of 3, we multiply it by itself, and then multiply the result by the original number again. This is also called cubing the number. In general, if b is any number and we raise it to the power of n, we have bn = b b b ... b (n times)

000 6.0000 141.9521 10.0000 334.1626

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